Abstract
We developed an optical fiber biosensor based on localized surface plasmon resonance in gold nanoparticles. The sensor system enables us to analyze biological molecules in ultra small amount of analytes. In spite of a simple optical setup, the limit of detection of avidin was about 0.09 μg/mL, which was similar to the value previously reported in a standard absorption experiment. Since the sensor probe is made at the endface of the optical fiber, it has following advantages: (1) it is easy to handle, and (2) it is possible to detect a small amounts of samples (<1μL) such as DNA and proteins. Because of the feature (2), it is possible to carry out DNA and protein detection with a sample solution of 100 nL.
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