Plasminogen activator inhibitor‐1 is negatively associated with fasting plasma monounsaturated fatty acids but not influenced by postprandial polyunsaturated fatty acid composition in men with high fasting triacylglycerol

Abstract

Increased consumption of dietary monounsaturated fatty acids (MUFA) is associated with a favorable risk factor profile associated with the metabolic syndrome (MetS), including lowered plasminogen activator inhibitor (PAI)‐1. In addition, the postprandial response to dietary fat has emerged as a dynamic metabolic period associated with MetS. Plasma fatty acid composition was measured in men with high fasting triacylglycerol (n=8, HTAG>1.69 mmol/L) and low fasting TAG (n=8, LTAG<1.7 mmol/L). Each subject underwent three postprandial oral fat tolerance tests (OFTT) of 1g/kg body weight emulsified lipids consisting of varied PUFA/saturated fatty acid (P/S) ratios of 0.2, 1.0 and 2.0, with blood collected through 8h. Fasting MUFA was negatively correlated with total PAI‐1 antigen (P<0.001, r=−0.98) and PAI‐1 activity (P<0.02, r=−0.8) in HTAG, but not LTAG. Fasting total PUFA concentration was positively correlated with total PAI‐1 antigen (P=0.03, r=0.75) in HTAG, but not LTAG. There was no difference in postprandial PAI‐1 total or activity in response to three OFTTs with similar MUFA but varied PUFA TAG composition. These data suggest that elevated MUFA concentrations may have beneficial effects on PAI‐1 in HTAG subjects and that postprandial PUFA concentrations do not influence postprandial PAI‐1 in this population.Supported by the Ontario Ministry of Agriculture, Food and Rural Affairs (OMAFRA) and NSERC