Abstract
Polymyxins — polymyxin B and polymyxin E (colistin) — are drugs of last resort in treating multidrug-resistant gram-negative infections. Previously, colistin resistance was attributed to chromosomal mutations and was not known to disseminate widely. Prompted by an observed increase in colistin resistance in isolates from food animals in China, investigators sought the mechanism. They ultimately identified plasmid-mediated colistin resistance (MCR-1) in Escherichia coli from a …
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