Abstract
Plasmacytoid dendritic cells (PDC) derive from a common lymphoid progenitor.The phenotypic features and functions of PDC are distinct from that of conventional myeloid DCs.PDC have been proven to play a important role in antiviral immune response.They also induce T cells anergy and the generation of regulatory T cells for immune tolerance.The mechanisms of immune tolerance is associated with the indoleamine 2,3-dioxygenase (IDO)-tryptophan metabolism pathway and the inhibitory membrane molecules.To elucidate the mechanisms immune tolerance induced by PDC may provide novel therapeutic approaches for diseases related to abnormal immune tolerance,such as persistent infection,tumor and autoimmune diseases. Key words: Plasmacytoid dendritic cell; Anergy; Regulatory T cell; Immune tolerance
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