Plasma vitamin D and serum total immunoglobulin E levels in patients with seasonal allergic conjunctivitis

Abstract

To evaluate plasma 25-hydroxyvitamin D and serum total immunoglobulin E (IgE) levels in patients with seasonal allergic conjunctivitis (SAC). This observational case-control study involved 49 patients with SAC without any other ocular and systemic diseases, and 44 consecutive, age- and sex-matched healthy subjects. Plasma 25-hydroxyvitamin D and serum total IgE levels of all subjects were quantified with electrochemiluminescence technique. Results were compared between the groups, and p values of <0.05 were considered as statistically significant. No significant differences were found between the groups with respect to age (p=0.41) and sex (p=0.98). Plasma vitamin D levels of the subjects with SAC (median 8.03ng/ml, range 3.00-17.97ng/ml) were significantly lower than the control group (median 10.52ng/ml, range 3.30-25.92ng/ml) (p=0.007). Serum total IgE levels of patients with SAC (median 48.65IU/ml, range 1.77-812.00IU/ml) were significantly higher when compared to the control group (median 32.49IU/ml, range 0.14-104.60IU/ml) (p=0.003). We found lower plasma vitamin D levels and higher serum total IgE levels in patients with SAC.