Abstract
BackgroundFree-range cattle are common in the Northeast China area, which have close contact with farmers and may carry virus threatening to cattle and farmers.MethodsUsing viral metagenomics we analyzed the virome in plasma samples collected from 80 cattle from the forested region of Northeast China.ResultsThe virome of cattle plasma is composed of the viruses belonging to the families including Parvoviridae, Papillomaviridae, Picobirnaviridae, and divergent viral genomes showing sequence similarity to circular Rep-encoding single stranded (CRESS) DNA viruses. Five such CRESS-DNA genomes were full characterized, with Rep sequences related to circovirus and gemycircularvirus. Three bovine parvoviruses belonging to two different genera were also characterized.ConclusionThe virome in plasma samples of cattle from the forested region of Northeast China was revealed, which further characterized the diversity of viruses in cattle plasma.
Highlights
Free-range cattle are common in the Northeast China area, which have close contact with farmers and may carry virus threatening to cattle and farmers
We report on the discovery of CRESSDNA genomes in the blood virome of cattle raised in the forest area of Northeast China
Our analysis characterizing enriched viral particle associated nucleic acids in cattle plasma showed that CRESSDNA virus and bovine parvovirus sequences are present in all the five libraries and yielded the most reads relative to other viruses
Summary
Free-range cattle are common in the Northeast China area, which have close contact with farmers and may carry virus threatening to cattle and farmers. Large-scale cattle farms account for an increasing part in the beef industry in China, free-range cattle raising is still used especially in the Northeast China area. Because free-range cattle have close contact with farmers, virus transmission from cattle to farmers through biting flies widely distributed in forested regions of Northeast China may conceivably occur. Rep-encoding, ssDNA (CRESS-DNA) genomes consist of a large and highly diverse collection of viruses [1,2,3] that infect a wide range of cellular hosts including vertebrates (Circoviridae), plants (Geminiviridae and Nanoviridae), crustaceans [4, 5], and fungi (SsHADV) [6].
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