Abstract
Plasma phospholipid fatty acid composition reflects, to a moderate degree, the fatty acid composition of the diet. To determine whether plasma phospholipid fatty acid composition might influence factor VII coagulant activity (factor VII c, we examined 2207 middle-aged adults free of diabetes and cardiovascular disease. Factor VII c was associated positively with the percentage of fatty acids that was saturated, and it was associated negatively with the linoleic acid percentage and the phospholipid polyunsaturated/ saturated fatty acid ratio. For example, a 1.9% greater saturated fatty acid level was associated with approximately a 5% higher factor VII c. These results suggest a role for dietary fat composition, or related dietary patterns, in determining levels of factor VII c.
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