Abstract
BackgroundPlasma nutrient biomarkers may be associated with waist‐to‐height ratio (WHtR) in youth with type 1 diabetes (T1D).Design1,416 youth aged 3‐20 years at diagnosis were included at baseline and 1,178 youth had a follow‐up visit after 23 (range 16‐40) months. Data on plasma phospholipid fatty acids, desaturase activities and vitamins were obtained at baseline. Multiple linear regression was used with adjustment for demographic and diabetes‐related confounders. Findings were stratified by weight status when significant (P<0.05) effect modification was observed.ResultsIn cross‐sectional analysis, palmitic acid (P=0.001), dihomo‐γ‐linolenic acid (DGLA, P=0.003) and Δ6‐desaturase (D6D, P=0.0004) were positively; oleic acid (P=0.014), linoleic acid (LA, P=0.002) and vitamin D (VD, P<0.0001) were negatively associated with WHtR. In normal weight youth, VD (P=0.003) was negatively associated with WHtR. In obese youth, DGLA (P<0.0001) and D6D (P<0.0001) were positively; Δ9‐desaturase‐18 activity (P=0.011) and VD (P<0.0001) were negatively associated with WHtR. In longitudinal analysis, baseline LA (P=0.017), n‐6/n‐3 fatty acid ratio (P=0.017), VD (P=0.003) and vitamin E (P=0.0001) were negatively associated with WHtR at follow‐up only in obese youth.ConclusionsPlasma nutrient biomarkers are associated with WHtR in T1D youth, most commonly among those who are obese.
Published Version
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