Abstract
A UFLC/MS-IT-TOF method is applied for plasma metabonomics study of depression-atherosclerosis rat model treated with the traditional Chinese medicine Tongxinluo.The results show that the abnormality of the amino acid metabolism,β-oxidation of fatty acid,cholesterol metabolism and lecithin metabolism occurred in the body of the model rat.The traditional Chinese medicine Tongxinluo regulates the metabolism of tryptophan,phenylalanine and some bile acids,finally inhibites the generation of depression-atherosclerosis.This study also shows that the metabonomics has a bright prospect in the efficacy evaluation and active mechanism elucidation of the traditional Chinese medicines.
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