Plasma markers of endothelial dysfunction in patients with hypertensive disorders of pregnancy: a pilot study in a South Indian population

Abstract

Objectives: To assess the plasma markers of endothelial dysfunction: VonWillebrand factor (vWF), Platelet derived microparticles (PMPs), and Endothelin-1 (ET-1) in various types of hypertensive disorders of pregnancy and correlate with the pregnancy outcome.Methods: Plasma levels of vWF, PMPs and ET-1 were analyzed by ELISA kits in gestational hypertension (GH), late onset preeclampsia (LOPE), early onset preeclampsia (EOPE), eclampsia (E) and control pregnant women (CPW) during third trimester. The gestational age at the time of delivery (GA) and birthweight (BW) of the baby also were measured.Results: The GA and the BW of the baby were found to be significantly lower in EOPE and eclampsia compared to CPW, GH and LOPE. The circulating levels of markers of endothelial dysfunction: vWF, PMPs and ET-1 were significantly higher in EOPE and Eclampsia compared to CPW, GH. Also a negative correlation was observed between vWF levels with pregnancy outcome; GA and BW.Conclusions: A generalized endothelial dysfunction and poor birth outcomes were observed in hypertensive disorders of pregnancy. There is a spectrum of biochemical derangements related to endothelial dysfunction in GH, EOPE, LOPE and E in that order.