Abstract
The concentrations of individual free fatty acids in plasma were determined in a group of patients who had suffered a myocardial infarction and in control subjects. The patients had lower concentrations of free octadecatrienoic and arachidonic acids and a higher concentration of eicosatrienoic acid, compared to the controls. The relationships between the concentrations of these fatty acids suggest that both trienoic acids belong to the linoleic acid series of polyunsaturated fatty acids. The changes in the concentrations of polyunsaturated free fatty acids are compatible with a block in the conversion of eicosatrienoic to arachidonic acid in the subjects with clinical atherosclerotic disease. Long-term tolbutamide treatment had no significant effect on the plasma concentrations of free polyunsaturated fatty acids in postinfarction patients.
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