Abstract
ABSTRACT Plasma kinetics of a pharmacologic dose of porcine calcitonin (PCT) in man were investigated using a sensitive radioimmunoassay. A single intravenous injection of 1 mg of homogeneous PCT was given to 21 subjects (5 normal, 6 with osteoporosis, 5 with hyperparathyroidism and 5 with Paget's disease) and a continuous prolonged infusion was given to 5 normal subjects. Plasma disappearance after single injection or continuous infusion could be described as a sum of at least 2 exponential components with half-times of 2.4 (0.3) and 40.9 (6.2) min (mean and se). Metabolic clearance rate during continuous infusion was 846 (42) ml/min. The apparent volume of distribution was 21.4 (2.0)% of body weight. Substantial hypocalcemia was associated, in 4 of 5 patients with Paget's disease, with an increase in serum immunoreactive parathyroid hormone (iPTH) which was sustained for the duration of the hypocalcemia; in the other groups these responses were equivocal or absent. However, injection of homogeneous PCT ...
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