Abstract
SUMMARY The metabolic clearance rate (MCR) of porcine calcitonin in six gilts was 13·0 ± 0·7 (s.e.m.) ml/min/kg and in four isolated, perfused pig livers was 16·1 ± 1·1 ml/min, with constant infusions of porcine calcitonin and measurement of calcitonin concentration by radioimmunoassay. After single injections of 125I-labelled porcine calcitonin, the MCR of 125I-labelled porcine calcitonin was 29·2 ± 2·8 ml/min in six isolated, perfused pig livers. 125I-labelled salmon calcitonin was cleared at a slower rate than porcine calcitonin after single injections into the gilt. 125I-Labelled human calcitonin and 125I-labelled salmon calcitonin were not significantly cleared by the isolated, perfused pig liver.
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