Abstract
Plasma D-Dimer Level Correlates with Age, Metastasis, Recurrence, Tumor-Node-Metastasis Classification (TNM), and Treatment of Non-Small-Cell Lung Cancer (NSCLC) Patients.
Highlights
Lung cancer is the most common and deadly malignant tumor worldwide
This study found that the plasma D-D level of Non-small-cell lung cancer (NSCLC) patients was higher than that of healthy people, with significant differences, indicating that NSCLC patients are in a hypercoagulable state, which can cause venous thromboembolism (VTE) at any time [35]
This study found that after chemotherapy, the difference in the D-D level between two consecutive cycles was not significant, but a significant difference was found between the two cycles with a one-cycle interval, and the difference before and after treatment was significant, indicating that chemotherapy can well control the hypercoagulable state of NSCLC patients
Summary
Lung cancer is the most common and deadly malignant tumor worldwide. At the time of diagnosis, 80% of lung cancer patients are in the advanced stage, and the 5-year survival rate is less than 15%, posing a serious threat to human health [1, 2]. The hypercoagulable state, which is common in patients with malignant tumors, can result in thrombosis, such as pulmonary embolism, and is a leading factor of death [5,6,7]. Studies have found that the disordered coagulation function may be related to the occurrence and development as well as the clinical treatment and prognosis of malignant tumors [8, 9]. The complex mechanism of hypercoagulable state in patients with malignant tumors is closely related to the biological characteristics of the tumor and can lead to disordered coagulation and fibrinolysis system [12]. Studies have shown that fibrinogen (FIB), platelet (PLT), and cancer cells can form microthrombosis under a hypercoagulable state, so tumor cells can escape immune attack, leading to tumor metastasis [13, 14]. By analyzing the characteristics of D-D levels in NSCLC patients, we retrospectively explored the correlation of D-D levels to age, metastasis, TNM stage, and treatment methods, as well as the effect of D-D levels on a hypercoagulable state in NSCLC patients
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