Score of plasma fibrinogen and serum albumin level in the prognosis evaluation of patients with non-small cell lung cancer

Abstract

Objective To investigate the role of plasma fibrinogen and serum albumin level (FA) score in the evaluation of the prognosis of non-small cell lung cancer (NSCLC) patients. Methods A total of 120 patients with NSCLC in our hospital from Jan 2010 to Dec 2013 were selected as study subjects, all patients were confirmed by pathology.According to the FA score, the patients were divided into the FA score was 0 group (n=56), the FA score was 1 group (n=44), and the FA score was 2 group (n=20). The relationship between FA score and clinicopathological characteristics in NSCLC patients were analyzed.Univariate and multivariate unconditional Cox regression analysis were used to analyze the risk factors of prognosis in NSCLC patients, and cumulative survival curves were drawn by Kaplan-Meier method. Results There was no significant difference in age, sex, alcohol history, histological type and N staging of NSCLC patients with different FA scores (P>0.05), there was a statistically significant difference in smoking history, differentiation degree, TNM stage and T stage (P<0.05). Univariate and multivariate unconditional Cox regression analysis showed that FA score (2 points) was the risk factor affecting the progression free survival of NSCLC patients(P<0.05). TNM staging (stage Ⅱ, Ⅲ) and FA score (2 points) were the risk factors affecting the total survival rate of NSCLC patients (P<0.05). The survival curves of Kaplan-Meier showed that there was a statistically significant difference in progression free survival between NSCLC patients with different FA scores (P<0.05), and there was a statistically significant difference in the overall survival rate between NSCLC patients with different FA scores (P<0.05). Conclusions FA score can predict the prognosis of NSCLC patients. Key words: Carcinoma, non-small-cell lung; Plasma fibrinogen; Serum albumin; Cumulative survival rate