Abstract
Plasma cell cheilitis (PCC) is an unusual benign plasma cell proliferative disease of an unknown etiology that clinically presents as erythematous-violaceous plaques, ulcerations, or eruptions often affecting the lower lip. PCC is known to respond poorly to corticosteroid treatment. A 43-year-old male presented with multiple painful hemorrhagic crusts on the lower lip that had developed over 1 month. An incisional biopsy was performed and microscopy showed a bandlike inflammatory cell infiltration composed mainly of plasma cells in the connective tissue. Immunohistochemistry confirmed a reactive nature of plasma cells. Thus, the diagnosis of PCC was established. Initially, the patient was treated with topical corticosteroids over 1 month, but had a relapse 3 months after complete remission. Then, we proposed the use of topical corticosteroids with cryotherapy. No recurrence was observed after 8 months of follow-up. In conclusion, cryotherapy associated with topical corticosteroids appears to be a successful option to control the relapses of PCC.
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