Abstract
SummaryTo search for a possible relationship between gonadotrophin secretion and catecholamines, blood samples were taken from women with normal ovulatory cycles and from those with disturbances of ovulation. Two catecholamine metabolites, 3-methoxy-4-hydroxyphenylglycol (MHPG) as a marker of adrenergic activity and 3,4-dihydroxyphenylacetic acid (DOPAC) of dopaminergic activity, were measured by high performance liquid chromatography. The mean level of MHPG in those with polycystic ovary syndrome was higher than in the group with normal ovulatory cycles. No change was found in MHPG or DOPAC levels after LH-RH administration. The MHPG levels were elevated after oestrogen injection in those with normal ovulatory cycles. Thus, in vivo, catecholamines may have an influence on gonadotrophins.
Published Version
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