Abstract
Plasma samples from normal and acromegalic and patients were fractionated by gel filtration and then concentrated by ultrafiltration. The amounts of protein, immunoreactive HGH (IR-HGH), and the in vitro sulfation factor (SF) activity of the fractions were determined and expressed per 0.1 distribution coefficient (Kd) intervals. More than 50% of the total IRHGH in all plasmas was eluted in a molecular size range greater than extracted pituitary HGH (ep-HGH), indicating plasma IR-HGH activity in a molecular size larger than ep-HGH or in association with other plasma proteins. Significant IR-HGH activity was found in the Kd areas corresponding to a molecular size smaller than ep-HGH. Acromegalic patient plasma showed a relatively greater amount of IR-HGH in the ep-HGH molecular size area compared to normal plasma. The maximal total SF activity occurred in a molecular size range greater than ep-HGH but the maximum SF potency of the eluted proteins, prior to Kd 0.65, occurred in the ep-HGH molecular size area...
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