Abstract
The metabolic changes are characterized initially by biochemical alterations in the body fluids (blood, urine, ruminal fluid) and thereafter by reductions in the quantity and quality of milk production, susceptibility to diseases, infertility and increases in morbidity and mortality in calves. Metabolic profiles can be used as monitoring methods for the diagnosis and prevention of subclinical metabolic diseases, for investigation of herd health problems or suboptimal herd performance and for the diagnosis of nutritional deficiencies.3,5,14
 The objectives of this research were to determine the dynamics of biochemical parameters in plasma and urine in Holstein-Friesian first-calf heifers.
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