Abstract
1. 1. Lipid and zinc analyses were conducted on liver mitochondrial and microsomal membranes as well as erythrocyte ghosts for streptozotocin (STZ) treated animals. 2. 2. In STZ animals, analysis of phosphatidylcholine (PC) and phosphatidylethanolamine (PE) fatty acids revealed an increase in palmitic acid and a corresponding decrease in stearic acid. 3. 3. Polyunsaturated fatty acid were also affected, with an increase in 18:2, decrease in 20:4 and an increase in 22:6 in STZ animals compared to controls. 4. 4. The change in fatty acid composition was obsrved in all three membrane fractions. 5. 5. Plasma zinc levels in STZ animals were elevated while no difference was observed in membrane bound zinc. 6. 6. Thus, while there appears to be both altered trace metal as well as membrane lipid metabolism in STZ treated animals, membrane bound zinc does not seem to be affected.
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