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Abstract
(1) Total alkaline phosphatase (TP) and heatstable alkaline phosphatase (HSP) activity was examined in the blood plasma during the terminal six weeks of pregnancy. Progressively rising levels of TP and HSP were observed in each of 22 healthy women and of 19 women with abnormalities during pregnancy. (2) Diabetes mellitus in pregnancy is associated with lower plasma levels of HSP and TP than are found at the same period of gestation in normal pregnancy. Three patients with pre-eclamptic toxaemia had higher than normal levels of plasma HSP. (3) Owing to its low and variable rate of metabolism plasma HSP has no value as a test of placental function.
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