Abstract
It was shown that myxoma virus produced plaques on monolayers of rabbit kidney cells or rabbit heart fibroblasts and that fibroma virus produced visible foci of infection on monolayers of rabbit kidney cells. This allowed development of plaque-count assays for the two viruses. With each virus the numbers of plaques produced were linearly related to virus concentration, and plaque formation was inhibited by specific antiserum. The plaque assay for each virus was at least as sensitive as the intradermal assay in rabbits, and the plaque assay for myxoma virus was more sensitive than the pockcount assay on the CAM of the chicken embryo. The fibroma virus focus of infection on monolayers of rabbit kidney cells under agar consisted of a small pile of cells easily differentiated from the focus of damaged cells produced by myxoma virus.
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