Abstract

The AcrAB/TolC efflux pump-mediated drug resistance in gram-negative bacteria might be controlled by efflux pump inhibitors (EPIs). This study was planned to discover a compound from plants that can be used as an EPI. Forty isolates of K. pneumoniae and 33 different plants were collected. The methanolic extracts of parts of plants were prepared. Chloramphenicol, tetracycline, and Ciprofloxacin were used for the sensitivity assay. Plant extracts were tested for EPI activity using Berberine and Et

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