Abstract

Fourteen multistereogenic symmetric and asymmetric salens based on a [2.2]paracyclophane skeleton have been tested as catalysts for the enantioselective addition of diethylzinc to aldehydes affording the corresponding alcohols in up to 94% enantiomeric excess. Chiral [2.2]paracyclophane hemisalens are applied for the first time as chiral ligands in the Et 2Zn addition to benzaldehyde.

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