Abstract
Chiral bidentate aryl- and alkyl phosphines (0.5%) coordinated to copper(II) triflate (0.5%) are efficient catalysts for the asymmetric conjugate addition of diethyl zinc to cyclohexen-2-one, chalcone and benzalacetone. Among the chiral phosphines tested, (S)-Norphos, (S,S)-Chiraphos and (R)-Prophos gave the best enantiomeric excesses (44%, 44% and 36% respectively).
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