Planar chromatographic direct separation of some aromatic amino acids and aromatic amino alcohols into enantiomers using cyclodextrin mobile phase additives

Abstract

Some racemic aromatic amino acids and amino alcohols were directly resolved using cellulose phase thin-layer chromatography with mobile phases containing highly concentrated solutions of cyclodextrin (β or α). Enantiomeric resolution is highly dependent on the mobile phase composition and on the structure of the compounds. The common feature of the compounds resolved in this study is that a polar group (amino or hydroxy) is attached at the para-position in the aromatic ring. It was found that the retention order of enantiomers of amino acids is opposite to that observed for the amino alcohol series.