Abstract

Primary maternal infection with cytomegalovirus during the second trimester of pregnancy with infection of the placenta, but sparing the fetus, is recorded. Because the mother was being tested in a prospective study it was possible to demonstrate the development of cytomegalovirus complement-fixing antibodies between 14 and 19 weeks of pregnancy, and of viruria at 25 weeks. The development of neutralizing antibodies in the mother's serum confirmed that her infection was a primary one. The baby was healthy at birth, and cytomegalovirus was not isolated from many specimens of urine and oropharyngeal swabs collected soon after birth and during the first year of life. His development has been normal. Primary maternal infection with cytomegalovirus during the second trimester of pregnancy with infection of the placenta, but sparing the fetus, is recorded. Because the mother was being tested in a prospective study it was possible to demonstrate the development of cytomegalovirus complement-fixing antibodies between 14 and 19 weeks of pregnancy, and of viruria at 25 weeks. The development of neutralizing antibodies in the mother's serum confirmed that her infection was a primary one. The baby was healthy at birth, and cytomegalovirus was not isolated from many specimens of urine and oropharyngeal swabs collected soon after birth and during the first year of life. His development has been normal.

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