Abstract
Placenta-specific protein 1 (PLAC1) is a unique onco-fetal-placental protein and an underappreciated therapeutic target in cancer
Highlights
Placenta-specific protein 1 (PLAC1) is a small (212 amino acid), secreted cell surface protein that was discovered because its location on the human and mouse X-chromosome coincided with genes suspected of being involved in placental and fetal pathology [1]
PLAC1 was discovered as a result of sequencing the region around the hypoxanthine ribosyltranferase 1 (HPRT) gene on the human X-chromosome based upon the suggestion that a placenta-specific protein is present in that region in the mouse genome [1]
A decade ago, Dr Lloyd Old wrote an editorial entitled “Cancer is a Somatic Cell Pregnancy” [36]. In that essay he reiterated the opinion of embryologist Dr John Beard, who in the late 19th century pointed out the near functional identity of tumors and placentas [37]
Summary
Placenta-specific protein 1 (PLAC1) is a small (212 amino acid), secreted cell surface protein that was discovered because its location on the human and mouse X-chromosome coincided with genes suspected of being involved in placental and fetal pathology [1]. Proximal), located at Exon 4, have been identified with experimental evidence that transcripts are simultaneously produced from both promoters in cells that express PLAC1 mRNAs [2,3,4]. Devor EJ (2016) Placenta-specific protein 1 (PLAC1) is a unique onco-fetal-placental protein and an underappreciated therapeutic target in cancer
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