Abstract
A cDNA cloned from its ability to stimulate inorganic phosphate uptake in Xenopus oocytes (phosphate uptake stimulator (PiUS)) shows significant similarity with inositol 1,4,5-trisphosphate 3-kinase. However, the expressed PiUS protein showed no detectable activity against inositol 1,4,5-trisphosphate, nor the 1,3,4,5- or 3,4,5,6-isomers of inositol tetrakisphosphate, whereas it was very active in converting inositol hexakisphosphate (InsP 6) to inositol heptakisphosphate (InsP 7). PiUS is a member of a family of enzymes found in many eukaryotes and we discuss the implications of this for the functions of InsP 7 and for the evolution of inositol phosphate kinases.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.