Pituitary and ovarian responses after an application of a low dose of the luteinizing hormone-releasing hormone (LHRH)-lytic peptide conjugate during the preovulatory period in ewes

Bret A Mcleod,Genje Buenviaje,Pawel M Bartlewski,William Hansel

doi:10.7243/2049-7962-2-4

Abstract

Introduction Luteinizing hormone-releasing hormone (LHRH), a decapeptide synthesized by the hypothalamic neurosecretory cells, is a key regulator of the development of reproductive tissues and gonadal function [1-8]. However, the overexpression of LHRH receptors found in reproductive tissue cancers such as breast, prostate, ovarian and endometrial cancer has been associated with the

Highlights

Luteinizing hormone-releasing hormone (LHRH), a decapeptide synthesized by the hypothalamic neurosecretory cells, is a key regulator of the development of reproductive tissues and gonadal function [1,2,3,4,5,6,7,8]
The overexpression of LHRH receptors found in reproductive tissue cancers such as breast, prostate, ovarian and endometrial cancer has been associated with the undesirable progression of the disease [9,10,11,12,13,14,15,16,17]
The purpose of this study was to determine the effect of a lytic peptide conjugate LHRH-Phor21 on the anterior pituitary function and dynamic ovarian processes in an ovine experimental model

Summary

Introduction

Luteinizing hormone-releasing hormone (LHRH), a decapeptide synthesized by the hypothalamic neurosecretory cells, is a key regulator of the development of reproductive tissues and gonadal function [1,2,3,4,5,6,7,8]. LHRH receptors are expressed on extrapituitary cells and tissues including lymphocytes, mammary gland, ovary, and prostate [7,8,10,18]. The extrapituitary LHRH receptors may represent an additional target for the lytic action of cell disrupting peptides conjugated with LHRH. LHRH-lytic peptide conjugates act as molecular cytotoxic transporters carrying lytic peptides to tissues expressing complement receptors [9,15,19]. These synthetic conjugates are linear, positively charged, amphipathic and α-helical molecules. The entire process is completed within minutes after the lytic peptide interacts with the membrane [9]

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