Abstract
Metabolic inflammation is an essential event in obesity-induced diabetes and insulin resistance. An extract of the active phenolic component of black pepper (Piper nigrum), piperine, is well known to provide beneficial physiological effects. This study aims to assess the regulation of inflammatory signalling molecules in adipose tissue by Piperine using a high diet and sucrose-induced type II diabetic experimental model. Our results suggest that piperine has the potential as a therapeutic drug or dietary supplement.
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