Abstract
Pioglitazone, a popular antidiabetic drug, which was recently shown to be effective in the treatment of skin ulcers, was successfully encapsulated in polysaccharide nanoparticles and used as a bioactive component of the wound-dressing material based on modified bacterial nanocellulose. Alginate and hydroxypropyl cellulose were used as a matrix for the nanoparticulate drug-delivery system. The matrix composition and particles’ size, as well as drug encapsulation efficiency and loading, were optimized. Pioglitazone hydrochloride (PIO) loaded particles were coated with chitosan introduced into the crosslinking medium, and covalently attached to the surface of bacterial nanocellulose functionalized with carboxyl groups. PIO was released from the surface of the hybrid material in a controlled manner for 5 days. Preliminary cytotoxicity studies confirmed safety of the system at PIO concentrations as high as 20 mg/mL. The obtained hybrid system may have potential application in the treatment of skin ulcers e.g., in diabetic foot.
Highlights
Diabetic foot ulcer is a main complication of diabetes mellitus
Bionanocellulose modified with carboxyl groups was kindly provided by Biovico®
The system was designed based on natural polysaccharides, ALG and Hydroxypropyl cellulose (HPC), which were highly biocompatible, as well as compatible with the proposed dressing, Modified Bacterial Nanocellulose (mBNC)
Summary
Diabetic foot ulcer is a main complication of diabetes mellitus. It significantly decreases the quality of life of diabetic patients and may lead to very serious complications, including leg amputation.In addition to the systemic treatment with antibiotics, wound-healing dressings are a crucial element of the therapy. Diabetic foot ulcer is a main complication of diabetes mellitus. It significantly decreases the quality of life of diabetic patients and may lead to very serious complications, including leg amputation. In addition to the systemic treatment with antibiotics, wound-healing dressings are a crucial element of the therapy. Among wound-healing materials used in diabetic foot syndrome hydrogels and hydrocolloids constitute an important and widely used class of materials. Hydrogels and hydrogel sponges allow to prevent infection, maintain moist environment, and absorb exudates [1]. They may serve as bioactive material designed to release active agents which stimulate healing process
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