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Cite Journal: Journal of Cell Science |  Publication Date: Feb 15, 2012 |
 Citations: 527 |
PTEN-induced kinase 1 (PINK1) and Parkin are mutated in many cases of early-onset familial Parkinson's disease (PD), but how these proteins are related to the pathogenesis of PD was unclear. Recently, work in cultured cells has shown that Parkin can mediate autophagy of damaged mitochondria (termed
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