Abstract
BackgroundThe clinical significance between particularly interesting new cysteine-histidine rich protein (PINCH) expression and radiotherapy (RT) in tumours is not known. In this study, the expression of PINCH and its relationship to RT, clinical, pathological and biological factors were studied in rectal cancer patients.MethodsPINCH expression determined by immunohistochemistry was analysed at the invasive margin and inner tumour area in 137 primary rectal adenocarcinomas (72 cases without RT and 65 cases with RT). PINCH expression in colon fibroblast cell line (CCD-18 Co) was determined by western blot.ResultsIn patients without RT, strong PINCH expression at the invasive margin of primary tumours was related to worse survival, compared to patients with weak expression, independent of TNM stage and differentiation (P = 0.03). No survival relationship in patients with RT was observed (P = 0.64). Comparing the non-RT with RT subgroup, there was no difference in PINCH expression in primary tumours (invasive margin (P = 0.68)/inner tumour area (P = 0.49). In patients with RT, strong PINCH expression was related to a higher grade of LVD (lymphatic vessel density) (P = 0.01)ConclusionsPINCH expression at the invasive margin was an independent prognostic factor in patients without RT. RT does not seem to directly affect the PINCH expression.
Highlights
The clinical significance between interesting new cysteine-histidine rich protein (PINCH) expression and radiotherapy (RT) in tumours is not known
PINCH expression in primary tumours PINCH protein expression was analysed at the invasive margin (Figure 1A) and inner tumor area (Figure 1B) of 137 primary tumours
There were no negative cases for PINCH either at the invasive margin or inner tumour area
Summary
The clinical significance between interesting new cysteine-histidine rich protein (PINCH) expression and radiotherapy (RT) in tumours is not known. Interesting new cysteine-histidine rich protein (PINCH) is a five LIM domain protein whose gene is located on chromosome 2q12.2. The PIP complexes provide crucial physical linkages between integrins and the actin cytoskeleton and transduce signals from the extracellular matrix to intracellular effectors [2,3]. These effectors further regulate the cytoskeleton organisation, spreading, Few have analysed the relationship between PINCH and radiotherapy (RT).
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