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Abstract
In this journal, Tagawa et al. [ [1] Tagawa A. Ono S. Inoue K. et al. A new familial adult-onset leukodystrophy manifesting as cerebellar ataxia and dementia. J. Neurol. Sci. 2001; 183: 47-55 Abstract Full Text Full Text PDF PubMed Scopus (15) Google Scholar ] report clinical, radiological and pathological observations in an autosomal dominant leukodystrophy that is thought to be new. However, the adult-onset, magnetic resonance images, and above all, the neuropathological findings strongly suggest that the condition is identical to the progressive white matter disorder in the family studied by Eldridge et al. [ [2] Eldridge R. Anayiotos C.P. Schlesinger S. et al. Hereditary adult-onset leukodystrophy simulating chronic progressive multiple sclerosis. N. Engl. J. Med. 1984; 311: 948-953 Crossref PubMed Scopus (107) Google Scholar ] and Schwankhaus et al. [ [3] Schwankhaus J.D. Katz D.A. Eldridge R. et al. Clinical and pathological features of an autosomal dominant, adult-onset leukodystrophy simulating chronic progressive multiple sclerosis. Arch. Neurol. 1994; 51: 757-766 Crossref PubMed Scopus (53) Google Scholar ]. The unique neuropathological features are the retention of oligodendroglia in the totally demyelinated and vacuolated white matter, and the relative lack of a glial response (Fig. 3A and C of Tagawa et al. [ [1] Tagawa A. Ono S. Inoue K. et al. A new familial adult-onset leukodystrophy manifesting as cerebellar ataxia and dementia. J. Neurol. Sci. 2001; 183: 47-55 Abstract Full Text Full Text PDF PubMed Scopus (15) Google Scholar ]).
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