Abstract
SUMMARY Clofazimine is a valuable drug for treatment of bacillary infection and for reactional states in leprosy. Side effects include redbrown skin pigmentation, darkening of the skin lesions; red coloration of urine, stools, sputum and sweat; and dryness of the skin and gastro-intestinal symptoms. Conjunctival pigmentation is the most common ocular side effect. Corneal and retinal changes have also been reported. We describe, for the first time, pigmentation of corneal nerves occuring in two patients, with the diagnosis of lepromatous leprosy, treated with clofazimine.
Highlights
CASE REPORT+ Trabalho realizado na Francis 1
Clofazim ine is phenazine deriva tive that has been used in the treat ment of leprosy for more than 20 years. It is valuable for the treatment of the bacillary infection, and for the immunological reaction in leproma tous leprosy, such as erythema nodosum leprosum (ENL) 1
Case 1 : A 28 years old Filipino man with a diagnosis of lepromatous leprosy, gave a history of progressive nodular skin lesions over his arms and ear lobes for 1 and a half years. He had been treated with triple therapy (Dapsone-Rifampin and Clofazimine ( l OOmg/day) for 6 months
Summary
Clofazimine is a valuable drug for treatment of bacillary infection and for reactional states in leprosy. Side effects include redbrown skin pigmentation, darkening ofthe skin lesions; red coloration ofurine, stools, sputum and sweat; an d dryness of the skin and gastro-intestinal sym ptoms. Conj unctival pigmentation is the most common ocular side effect. Corneal and retinal changes have been reported. For the first time, pigmentation of corneal nerves occuring in two patients, with the diagnosis of lepromatous lcprosy, treated with clofazimine.
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