Abstract
The polyoxometalate dysprosium cluster, (Dy–S–W POM) , Na10[Dy2W10O30(µ-S)6]·80H2O, shows remarkable dsDNA denaturation property. In the presence of 0.22 µmol of this Dy–S–W POM, the melting temperature (Tm) of calf-thymus (CT) dsDNA is decreased to 62.35 °C. Dy–S–W POM shows bleaching of methylene blue (MB). Addition of CT-DNA in the MB bleached solution of Dy–S–W POM apparently intercalates MB. Such trapped MB by CT-DNA responds to its re-oxidation by elemental sulfur formed in the bleaching process involving Dy–S–W POM. This reduction–oxidation property of MB with Dy–S–W POM led to the detection of pico (13.20 pmol) level of DNA even by naked eye, which will be helpful for rapid trace DNA detection in forensic science and DNA-related diagnostics, complimenting time-consuming sophisticated methodology.
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