Phytosomes in herbal formulation: an updated review

Abstract

Phytosomes, a phospholipid-based self-assembled delivery system, can improve oral bioavailability of polyphenolic compounds. These systems, prepared by reacting polyphenolic phytoconstituents with phospholipid, can enhance the passage of lipophilic herbal constituents across the lipid membrane. Phytosomes are used in various herbal drugs like Ginkgo biloba,Camellia sinensis. Recent advancements in phytosomes technology have led to the development of transdermal routes for delivering phytoconstituents. These products are increasingly used in dietary supplements for homeostatic management of inflammation, toxicities, cancers, and weight loss. This technique increases the hydrophilicity of highly lipophilic drugs, making them suitable for drug delivery and allowing hydrophilic phytoconstituents to cross biological membranes. Researchers are exploring the transdermal route as a potential way to deliver phytoconstituents, which are increasingly being used in dietary supplements for homeostatic management of various diseases. We will explore an updated review of Phytosomes in herbal formulation.