Abstract
This study was carried out to investigate the therapeutic role of the ethanolic extract of Pleurotus cornucopiae on sodium arsenite induced nephrotoxicity in rats. Sodium arsenite at the dose of 8 mg•kg–1 body weight orally caused renal damage in rats as manifested by the significant rise in serum levels of serum urea, uric acid and creatinine level compared with control. Ethanolic extracts of P. cornucopiae (400 mg•kg–1 body weight per day) was administered orally for 30 days to sodium arsenite pre-treated rats. The results show significant decrease in the serum urea, uric acid and creatinine levels in comparison to the arsenic treated denotes the nephroprotective effect of P. cornucopiae against sodium arsenite induced toxicity. Furthermore, it also possesses antioxidant effect as lipid peroxidation (MDA) levels decreased in P. cornucopiae treated group in comparison to arsenic treated group. Thus, the present study reveals that P. cornucopiae possesses nephroprotective as well as antioxidant property against arsenic induced toxicity.
Highlights
Arsenic is one of the most dangerous occupational and environmental toxins
Fresh fruiting body of Pleurotus cornucopiae were collected from the Rajendra Agriculture University (RAU), Pusa, Samastipur, Bihar, India
Arsenic intoxicated group showed a significant increase in serum uric acid, urea and creatinine content as compared to control after acute treatments (p < 0.05)
Summary
Arsenic is one of the most dangerous occupational and environmental toxins. Both natural and anthropogenicHow to cite this paper: Suman, S., Ali, M., Kumar, R. and Kumar, A. (2014) Phytoremedial Effect of Pleurotus cornucopiae (Oyster Mushroom) against Sodium Arsenite Induced Toxicity in Charles Foster Rats. (2014) Phytoremedial Effect of Pleurotus cornucopiae (Oyster Mushroom) against Sodium Arsenite Induced Toxicity in Charles Foster Rats. Arsenic is abundant in the crust of the earth and is found in all environments It is found in soil, minerals, surface and groundwater [1]. Hepatoprotective effect of Pleurotus cornucopiae against arsenic induced toxicity in rats has been observed in recent studies [8]. With such a background, our initial aim was to find out suitable herb to modulate arsenic poisoning, which should be 1) easy to administer, 2) effective in low dose, 3) inexpensive, and 4) relatively safe
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