Abstract
Psidium guajava is an equatorial fern tree and nutritive plant with medicinal properties including antimicrobial, antioxidant, antitumor, anti-inflammatory activities, etc., In the present study, the untargeted phytometabolome of ethyl acetate and acetone extracts of P. guajava showed 107 compounds were identified using UPLC-ESI-Q-TOF-MSE analysis and assessed for anti-biofilm activity using various assays. The results clearly indicated that the ethyl acetate and acetone extracts significantly inhibit the growth and obliterate the metabolic activity of E. coli. The confocal laser scanning microscope (CSLM) analysis also confirmed the biofilm inhibitory activity of extracts against E. coli. Further, the ethyl acetate and acetone extracts displayed significant wound healing activity in BALB/c mice than the control treatment. The Doppler imaging analysis depicted that the extracts increase the blood circulation towards the wound to accelerate wound repair. Together, the UPLC-Q-TOF-MSE analysis clearly showed the metabolomics profiling of P. guajava and these metabolomes could be responsible for their potential biofilm obliterating and augmenting acute wound repair.
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