Abstract
BackgroundAdenanthera pavonina L. is an important medicinal plant and its barks are used in traditional medicine for treating different diseases. Therefore, a phytochemical investigation was carried out to isolate and identify secondary metabolites from its barks.ResultsSeven compounds namely ethyl 3,3-dimethyl-13-hydroxytridecanoate (1), stigmasta-5,22-dien-3β-ol (2), tert.butyl tridecanoate (3), 6-α-hydroxy stigmast-20(21)-en-3-one (4) of dichloromethane extract and 18-(2′, 3′-dihydroxyphenyl)nonadec-17-en-2-ol (5), 1-(N-propyl amino)-2-henecosanone (6), and stigmast–5(6), 20(21)-diene-3-one (7) were isolated from the barks of Adenanthera pavonina Linn. Of these compounds, 1, 4, 5, 6, and 7 appear new. The structures of these compounds were elucidated by spectroscopic techniques, mainly by NMR.ConclusionsFive new and two known compounds have been isolated and characterized from the bark of A. pavonina. The isolated compounds could be a potential template for the synthesis and development of new lead compounds with interesting pharmacological properties.Graphical abstract
Highlights
Adenanthera pavonina L. is an important medicinal plant and its barks are used in traditional medicine for treating different diseases
1 Background Adenanthera pavonina L (Bengali: Rakta kambal) is an erect medium-sized tree (6–15 m tall and up to 45-cm diameter) with dark brown to grayish bark belongs to the family Leguminosae
(2019) 8:20 spectra were recorded using Nicolet iS10 FT-Infrared spectroscopy (IR) spectrometer by potassium bromide (KBr) pellets. 1H Nuclear magnetic resonance (NMR), 13C NMR, Distortionless enhancement by polarization transfer (DEPT) 135 spectra, and attached proton test (APT) spectra were recorded in CDCl3, CD3OD, and mixture of CDCl3 and CD3OD with a 300-MHz NMR Spectrometer (Varian MERCURY-VX-300)
Summary
Adenanthera pavonina L. is an important medicinal plant and its barks are used in traditional medicine for treating different diseases. A phytochemical investigation was carried out to isolate and identify secondary metabolites from its barks. It is indigenous to India and Bangladesh in the South-eastern region [2]. Different parts of this plant have been used in traditional medicine for the treatment of various diseases. The anti-inflammatory, analgesic, antioxidant, cytotoxic, anti-diarrheal, acute toxicity, antibacterial, antifungal, and blood pressure-reducing activities of the bark, leaf, and seed extracts and its isolated compounds have been reported [6–13]. Previous phytochemical investigation reported the presence of many bioactive compounds like robinetin, chalcone, butin and flavanol ampelopsin,
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