Abstract
The fruit and decoction of Lycium shawii Roem and Schult (Solonaceae) aerial parts are used to prevent from liver damage in folk medicine. In the present study biological activities and phytochemical study of aerial parts of Lycium shawii R. Family Solanaceae were evaluated. Methylene chloride fraction exhibits potent inhibition of cell growth against MCF7 cancer cell. Ethyl acetate fraction has the highest radical scavenging activity as determined by DPPH assay. Ethyl acetate fraction showed the highest hepatoprotective activity against CCL4- induced hepatotoxicity compared to standard silymarin. Phytochemical study of bio-active fractions (Methylene chloride and Ethyl acetate) of L. Shawii R. resulted in isolation and structural determination of 5 compounds; 5,9-Heneicosadienoic acid methyl ester, β-Sitosterol, Atropine, Trans-Ferulic acid and 5- Hydroxy Ferulic acid.
Highlights
Genus solanum, known as nightshade plant is an economically important genus from which the family name (Solanaceae) was derived
Reported studies concerning Lycium shawii R. were limited to evaluation of the antioxidant activity using DPPH radical scavenging assay [15], the present study aimed to evaluate cytotoxic, in vitro antioxidant activity and in-vivo hepatoprotective activity of the hydroalcoholic fraction of Lycium shawii R., and the fraction thereof and phytochemical studying of bio-active fractions
The results revealed that n-hexane fraction exhibits potent inhibition of the cell growth of HCT116 cancer cells with IC50 value of 7.8 ± 0.197 μg/ml while methylene chloride fraction exhibits potent inhibition of the cell growth of MCF7 cancer cells with IC50 value of 11 ± 0.195 μg/ml. n-butanol fraction showed IC50 value of 9 ± 0.088 μg/ml for HePG2 cancer cells
Summary
Known as nightshade plant is an economically important genus from which the family name (Solanaceae) was derived. Antioxidant supplements are used to reduce oxidative damage from free radicals and active oxygen species. Synthetic antioxidants such as butylatedhydroxytoluene (BHT), butylatedhydroxyanisole (BHA) and trolox are widely used as antioxidants in the pharmaceutical and food industry. They have shown to have toxic and/or mutagenic effects [9], because of their toxicity, the use of natural antioxidants receives a lot of attention nowadays because they are less toxic [10]. The recent surge of interest in the chemistry of the genus resulted in isolation and identification of compounds of various classes of alkaloids, flavonoids, coumarins, sterols, and steroids, organic acids and their derivatives, polysaccharides, carotenoids, nutrients, and essential oils [14].
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