Abstract
Duguetia furfuracea, belonging to the Annonaceae family, is a perennial plant found in the Central-West, Southeast, and Northeast regions of Brazil, known for its various uses in traditional medicine. Used as a hypocholesterolemic, anorexigenic, and for treating various conditions including cancer and infections, its medicinal properties have garnered scientific interest. Studies have identified several bioactive compounds in different parts of the plant. The leaves contain phenolic acids, flavonoids, and alkaloids such as duguetine and dicentrinone, which exhibit antioxidant, anti-inflammatory, and antimicrobial properties. Phytochemical analysis revealed the presence of rare sesquiterpenes such as α-santalene and (-)-ishwarane, strengthening the chemotaxonomic relationship between Annonaceae and Aristolochiaceae. The species has shown larvicidal activity against Aedes aegypti, pediculicidal activity against Pediculus capitis, and antiplasmodial activity against Trypanosoma cruzi. Additionally, it possesses anti-inflammatory, antinociceptive, and cytotoxic activities, being effective against Candida spp. strains and cancer cells. However, its toxicity was observed in studies with Drosophila melanogaster and cellular models, indicating the need for further studies to ensure its safe use. The plant shows potential for therapeutic applications due to its chemical diversity, but it is essential to deepen investigations into its mechanisms of action and develop extraction and isolation methods to maximize its medicinal potential safely and effectively. Continued research is crucial to integrate D. furfuracea into modern phytotherapy and the development of new drugs. The presence of these bioactive compounds highlights the importance of exploring the full pharmacological potential of D. furfuracea for future therapeutic advancements, emphasizing its promising role in natural medicine. the pharmacological properties of D. furfuracea underscore its potential for innovative drug development and traditional medicinal enhancement.
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