Abstract
Clausena lansium Lour. Skeels (Rutaceae) is widely distributed in South China and has historically been used as a traditional medicine in local healthcare systems. Although the characteristic components (carbazole alkaloids and coumarins) of C. lansium have been found to possess a wide variety of biological activities, little attention has been paid toward the other components of this plant. In the current study, phytochemical analysis of isolates from a water-soluble stem and leaf extract of C. lansium led to the identification of 12 compounds, including five aromatic glycosides, four sesquiterpene glycosides, two dihydrofuranocoumarin glycosides, and one adenosine. All compounds were isolated for the first time from the genus Clausena, including a new aromatic glycoside (1), a new dihydrofuranocoumarin glycoside (6), and two new sesquiterpene glycosides (8 and 9). The phytochemical structures of the isolates were elucidated using spectroscopic analyses including NMR and MS. The existence of these compounds demonstrates the taxonomic significance of C. lansium in the genus Clausena and suggests that some glycosides from this plant probably play a role in the anticancer activity of C. lansium to some extent.
Highlights
The genus Clausena (Rutaceae) is comprised of approximately 30 species that are scattered throughout the subtropical and tropical regions, including China, Vietnam, Indonesia, Malaysia, and the Philippines [1,2]
The compounds demonstrates the taxonomic significance of C. lansium in the genus Clausena and suggests existence of these compounds demonstrates the taxonomic significance of C. lansium in the genus that some glycosides from this plant probably play a role in the anticancer activity of C. lansium to Clausena and suggests that some glycosides from this plant probably play a role in the anticancer some extent
The current study demonstrates the presence of the aromatic glycosides, sesquiterpene glycosides, and coumarin glycosides
Summary
The genus Clausena (Rutaceae) is comprised of approximately 30 species that are scattered throughout the subtropical and tropical regions, including China, Vietnam, Indonesia, Malaysia, and the Philippines [1,2]. The investigation resulted in the separation and characterization of five lansium was carried out. The investigation resulted in the separation and characterization aromatic glycosides (1–5), two dihydrofuranocoumarin glycosides (6,7), four sesquiterpene glycosides of five aromatic glycosides (1–5), two dihydrofuranocoumarin glycosides (6,7), four sesquiterpene (8–11), and one adenosine (12) (Figure 1). All compounds were isolated for the first time genus Clausena, including a new aromatic glycoside (1), a new dihydrofuranocoumarin glycoside (6), from the genus Clausena, including a new aromatic glycoside (1), a new dihydrofuranocoumarin and two new sesquiterpene glycosides (8 and 9). The known compounds were determined compounds were established using comprehensive spectroscopic studies.
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