Abstract
BackgroundSeveral phytochemical constitutes possess natural antioxidant activity and are in fact advantageous in reducing many oxidative stress related diseases. Drymaria diandra of Caryophyllaceae family is one such plant which exhibits various medicinal properties. The aim of the current study is to provide detailed exploration of phytochemical constitutes, metal concentration determination, antioxidant, and antibacterial activity of Drymaria diandra.ResultsQualitative phytochemical analysis showed the presence of maximum number of metabolites in methanol-water (1:1) extract. The heavy and toxic metals such as As, Cd, Cr, and Pb were almost near to the detection limit. The concentration of Fe (19.64 mg/l) was highest followed by Mn (2.35 mg/l). The (IC50) value for methanol extract was found 195.61 which is greater than the standard Ascorbic acid. Antibacterial activity of methanol extract was found higher for Staphylococcus aureus and Escherichia coli with 22-mm and 14-mm sized diameter of zone of inhibition respectively and methanol-water extract for Proteus vulgaris with 17-mm diameter of zone of inhibition.ConclusionThe findings of the present study showed the presence of various valuable phytochemical constitutes responsible to give antibacterial and antioxidant potency. The presence of bio-metals and the absence of toxic metals further highlight the importance of plant as the source of food that bears medicinal properties.
Highlights
Several phytochemical constitutes possess natural antioxidant activity and are advantageous in reducing many oxidative stress related diseases
The present study has aimed to evaluate the phytochemical constitutes and metal concentration determination of Drymaria diandra plant
We have extended our research to screen antibacterial and antioxidant activity of plant extracts
Summary
Several phytochemical constitutes possess natural antioxidant activity and are advantageous in reducing many oxidative stress related diseases. The emerging medical problems in commonly employed treatment processes are due to the antimicrobial toxicity and undesirable side effects and are considered the root cause of chemotherapeutic failure which needs extensive investigation to reshuffle drug candidates [1] Besides their synthetic procurement, several modern drugs with potential activity have been derived from natural resources and so, medicinal plants are focused in research to obtain new chemotherapeutic agents [2]. In Nepal, most of the species of drymaria are found in tropical and subtropical parts, extending from southern plane region to northern Himalayan region up to an elevation of 2100 m height [9] With insufficient knowledge, this plant has various traditional medicinal uses such as in treating cold, headache, coryza, bronchitis, as poultice on sore (to treat aching, inflamed, or painful parts), leprosy, tumors, as fumigant for eye troubles, as cerebral stimulant and antifebrile agent [10]. We have extended our research to screen antibacterial and antioxidant activity of plant extracts
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