Abstract
Objective: The aim of this study was focussed on phytochemical analysis, in vitro antioxidant activities of different solvent extracts of Hypoestes phyllostachya leaf.
 Methods: The leaves were washed efficiently, shade dried and coarsely powdered. The powdered leaf material of Hypoestes phyllostachya was successively extracted with hexane, chloroform, methanol and water using Soxhlet apparatus. Preliminary phytochemical screenings for polyphenolics, proteins, phytosteroids, flavonoids, tannins, glycosides, alkaloids carbohydrates, polyphenolics, saponins were done by following standard procedure. In vitro antioxidant activities of various solvent extracts were assessed using DPPH, ABTS, Hydroxy radical, total antioxidant capacity and reducing power assay. Polyphenolics and flavonoids were also estimated.
 Results: The results showed that most of the phytochemical compounds such as carbohydrates, proteins, steroids, fixed oils and fatty acids, flavonoids, alkaloids, saponins, tannins, polyphenolics and glycosides present in the methanolic and aqueous extract of Hypoestes phyllostachya. The in vitro antioxidant activity of Hypoestes phyllostachya leaf clearly showed that it has better antioxidant activity, which was confirmed by different assays.
 Conclusion: From this work, it can be concluded that Hypoestes phyllostachya has the potential to be a good antioxidant but have only a lesser amount of flavonoids and polyphenolic contents. This was the first report on the pharmacological activity of the Hypoestes phyllostachya.
Highlights
Herbal medicine contains rich varieties of free radical scavenging phytochemicals such as flavonoids, anthocyanins, carotenoids, dietary glutathione, vitamins and endogenous metabolites and they have antioxidant properties [1]
Phytochemical screening of different solvent extracts of the leaf material The hexane, chloroform and methanolic and aqueous leaf extract of Hypoestes phyllostachya were screened for the presence of phytochemical compounds
The qualitative analysis of methanolic and aqueous leaf extract showed the presence of carbohydrates, proteins, steroids, fixed oils and fatty acids, flavonoids, alkaloids, saponins, tannins and polyphenolics
Summary
Herbal medicine contains rich varieties of free radical scavenging phytochemicals such as flavonoids, anthocyanins, carotenoids, dietary glutathione, vitamins and endogenous metabolites and they have antioxidant properties [1]. Oxidative stress is defined as a “state in which oxidation exceeds the antioxidant systems in the body secondary to a loss of the balance between them. It causes dangerous effects such as peroxidation of lipids, oxidative DNA damage, and physiologic adaptation phenomena and regulation of intracellular signal transduction. Antioxidants are substances that inhibit oxidative stress to a target molecule [2] Antioxidants scavenge these free radicals due to singlet oxygen quenchers and redox hydrogen donators [3]. They prevent cellular damage by reducing oxidative stress and provide a beneficial effect on human health. Phytochemicals represent a potential source of new compounds with antioxidant activity as it contains large amounts of antioxidants such as Ascorbic acid, Tocopherol, flavonoid and polyphenolic compounds
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