Abstract
The methanol pulp extract of Ziziphus mauritiana was investigated for the presence of bioactive substances and antibacterial activity against Escherichia coli, Staphyloccus aureus, Salmonela typhi and Bacillus subtilis using the agar diffusion method. The result of phytochemical test indicated that tannins, flavonoids, saponin, cyanogenic glycosides, and terpenoids were present in pulp. The result of antibacterial studies indicates that the crude extract as well as fractions possesses significant activity against the tested organisms. The extract and its fraction also possess good inhibitory activity; hence can be used as antibacterial agent.
Highlights
Bioactive components are naturally found everywhere in most dietary higher plants available to humans and livestock
Plants used for the treatment of diseases is as old as mankind, medicinal plants are an important source of potentially useful structures for the development of new chemotherapeutic agents
The first step towards achieving this goal is the in vitro [6] antibacterial activity studies [5] which reported that the methanol leaf extracts of Ziziphus mauritiana showed significant activity against some certain bacteria and shows potentials to have powerful antibacterial effect
Summary
Bioactive components are naturally found everywhere in most dietary higher plants available to humans and livestock. The natural products such as plant extracts provide unlimited opportunities for new drug discoveries, mostly because of plethora of varieties of phytochemicals [1,2]. Reports [7,8,9] on the antiviral, antibacterial, antifungal, anthelmintic, antimolluscal and anti-inflammatory properties of plants, some of these observations have helped in identifying the active phytochemicals responsible for such therapeutic activities and in developing synthetic drugs for the treatment and management of a number of ailments in human beings. In this work Phytochemical Screening and Antimicrobial Activity of the pulp extract and fractions of Ziziphus Mauritiana was investigated against Escherichia coli, Staphyloccus aureus, Salmonela typhi and Bacillus subtilis using the agar diffusion method
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