Abstract
Possible Revival of Atrophied Islet Cells of the Pancreas by Vernonia amygdalina in Alloxan Induced Diabetic RatsJosiah J. Sunday, Nwangwu C. O. Spencer, Omage Kingsley, Abdulrahamon A. Akintola, Nkwonta Binyelum and Aderoju O. Favour.
Highlights
The current epidemic of diabetes mellitus (DM) in Africa, coupled with impinging poverty, clearly indicates the urgent need to develop new therapeutic drugs of cheaper and more available to face this growing health challenge
Hyperglycemia was induced by the injection of 150 mg/kg (i.p.) of alloxan monohydrate freshly dissolved in physiological saline
The activity was compared with reference standard glibenclamide (2 mg/kg, p.o.) and negative control of physiological saline
Summary
The current epidemic of diabetes mellitus (DM) in Africa, coupled with impinging poverty, clearly indicates the urgent need to develop new therapeutic drugs of cheaper and more available to face this growing health challenge. Diabetes mellitus is a major illness of the human race implicated with numerous clinical manifestations. It is a clinical syndrome characterized by chronic hyperglycemia (defects in insulin secretion, insulin action or both) resulting in aberration in carbohydrate, fat and protein metabolism. It has been reported that the chronic hyperglycemia of diabetes is associated with complications like renal failure, coronary artery disorder, neurological complications, cerebro-.
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