Abstract
s. PHYTOPHARM 2012 M 72 Obzory po kliniceskoj farmacologii i lekarstvennoj terapii [Reviews of clinical pharmacology and drug therapy] ТОМ 10/2012/2 PHYTOCHEMICAL RESEARCH OF FILIPENDULA ULMARIA AND FILIPENDULA HEXAPETALA © Kruglova M.J, Kruglov D. S., Fursa N. S. Novosibirsk State Medical University, Russia Yaroslavl State Medical Academy, Russia The herbal medicines made from Filipendula ulmaria Maxim. are used in folk and applied medicine. They have anti-inflammatory and astringent activity. Along with this plant, F. hexapetala Gilib. is also a wide-spread plant of the genus Filipendula. The aim of work is the comparative phytochemical research of above-ground part of these plants. The above-ground parts of investigated plants were collected in Novosibirsk region in flowering stage. The collected raw materials were dried before the measuring. The amount of polysaccharides, amino acids and phenol compounds were measured by means of hPlC. identification of components was done by the way of comparison with the standard substances. As a result it was established that both species have similar monosaccharide and amino acid structures (The amount of polysaccharides and amino acids was calculated for the absolutely dry raw material and equaled 7,0–8,5 % and 8,3–10,3 %). for the first time methylcoumarin was discovered in the investigated plants. Also it was established that qualitatively the primary and secondary metabolites of two species of Filipendula are alike, which is in agreement with known data. There are only insignificant differences in the quantitative amount of components and this fact allows to assume a similar pharmacological activity of phytomedicines which can be made from both species studied. Table. The content of phenol compounds F. ulmaria and F.hexapetala Сompound Relative amount, % f. ulmaria f. hexapetala Gallic acid 18,06 22,23 Catechine 3,50 2,66 Chlorogenic acid 9,57 3,77 Neochlorogenic acid -* 1 3,93 Cichoric acid 4,25 4,04
Highlights
For the first time methylcoumarin was discovered in the investigated plants
The herbal medicines made from Filipendula ulmaria Maxim. are used in folk and applied medicine
Original FP (OFP), generic FP (GFP), innovative combinations of registered FP, registered FP in new pharmaceutical forms (PhF), new dosage and new administration way are subject to State Registration (SR) in Russia
Summary
For the first time methylcoumarin was discovered in the investigated plants. it was established that qualitatively the primary and secondary metabolites of two species of Filipendula are alike, which is in agreement with. PHYTOCHEMICAL RESEARCH OF FILIPENDULA ULMARIA AND FILIPENDULA HEXAPETALA The herbal medicines made from Filipendula ulmaria Maxim.
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