Abstract
In this study, the in vitro results confirmed the anticancer efficacy of ethanolic extracts obtained from leaves of Ocimum basilicum, Aegle marmelos and Hibiscus rosa-sinensis. Alkaloids, terpenoids, steroids and flavonoids were all present in significant amounts in all the ethanolic extract. The O. basilicum extract contained 16 phytochemicals, of which 10 showed indications of bioactivity. A. marmelos extract contains 20 phytocompounds, 13 of which were bioactive, whereas the H. rosa-sinensis extract comprised total 25 different compounds and only 11 compounds of which have bioactive properties. The study examined the phytocompounds found in the leaves of O. basilicum, A. marmelos and H. rosa-sinensis plants and their ability to inhibit certain lung cancer cell lines proteins (PDB ID: 6LTK). The O. basilicum plant leaves contain phytocompounds, which are more active against lung cancer than A. marmelos and H. rosa-sinens extracts. The molecular docking research results indicated that mesterolone (-8.8 kcal/mol) possesses significant potential as an inhibitor of the lung cancer (6LTK) cell line protein as a prospective therapeutic option and analogous to the conventional application of the studied plants.
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